Ammonia
A necessary toxin. Ammonia is produced when protein is metabolized and by gut bacteria. The liver's urea cycle converts it to urea for kidney excretion. When this system fails or is overwhelmed, ammonia accumulates—causing brain fog, fatigue, and cognitive issues.
Sources of Ammonia
Protein Metabolism
Amino acid breakdown produces ammonia. Normal but must be processed. More protein = more ammonia.
Gut Bacteria
Bacteria produce ammonia from protein. Dysbiosis can increase production. Constipation worsens.
Muscle Breakdown
Exercise, stress, catabolism release amino acids. Ammonia byproduct of muscle metabolism.
Kidney Issues
Kidneys excrete urea. Kidney dysfunction impairs elimination. Ammonia builds up.
Signs of Elevated Ammonia
Brain Fog
Ammonia crosses blood-brain barrier. Affects neurotransmitters. Confusion, poor concentration.
Fatigue
Impairs energy production. Mitochondrial effects. Unexplained tiredness.
Exercise Intolerance
Can't recover from exercise. Crashes after activity. Ammonia accumulates during exertion.
Mood Issues
Irritability, anxiety. Ammonia affects GABA. Brain chemistry disruption.
Protein Sensitivity
Feel worse with high protein meals. Ammonia production overwhelms processing.
Supporting Ammonia Clearance
L-Ornithine
Urea cycle support. Helps convert ammonia. 500-2000mg before bed or exercise.
Alpha-Ketoglutarate
Binds ammonia in brain. Creates glutamate. AAKG supplement form.
Yucca Root
Binds ammonia in gut. Reduces bacterial ammonia. Traditional use.
Activated Charcoal
Binds toxins in gut. Can reduce ammonia absorption. Away from other supplements.
Probiotics
Balance gut bacteria. Reduce ammonia-producing species. Support healthy microbiome.
Regular Bowel Movements
Constipation increases ammonia reabsorption. Keep things moving. Fiber, magnesium.