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Methionine adenosyltransferase 1A – enzyme that converts methionine to SAMe. Rate-limiting for methylation.

Key Information

Function
Methionine + ATP → SAMe
Location
Liver primarily
Deficiency
Hypermethioninemia, fatty liver

Connected Pathways

Methionine

Amino Acids

Essential sulfur amino acid. Precursor to SAMe and cysteine.

SAMe

Methylation

S-Adenosylmethionine. Universal methyl donor for hundreds of reactions including neurotransmitter metabolism.

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Pathwaymap.com is my attempt at connecting my understanding with the data available. I am trying to keep my bias out of what I write on this site. But this actually introduces a problem I am still trying to solve. Some of the data refers to folic acid or methylfolate, and I do not agree with either, but there is more to this story that requires explaining. This is just one example. If you continue following my content you will likely hear me explain these various details along the way.

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I figured out how nutrients work and its kinda neat youtube.com/watch?v=0J8Qt6GC6FE

We’re doing it wrong  youtube.com/watch?v=qAxodqhpEkA

My old factory video from before I learned how to complicate this youtube.com/watch?v=0I3dWYbQpX4

If you are interested in iodine whyiodine.com

If you are trying to sort out the genetics situation methylate.me

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