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5-MTHF – active form of folate. Directly usable without MTHFR conversion.

Key Information

Benefits
Bypasses MTHFR mutations
Caution
Can cause anxiety, overmethylation in sensitive individuals
Dose
Start very low (100-200mcg)

Connected Pathways

SHMT

Genes

Serine hydroxymethyltransferase - converts serine to glycine, generates one-carbon units.

Homocysteine

Methylation

Methylation cycle intermediate. Elevated levels indicate methylation issues or B vitamin deficiencies.

Folinic Acid

Nutrient Forms

5-formyl THF - natural reduced folate. Doesn't require MTHFR.

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Pathwaymap.com is my attempt at connecting my understanding with the data available. I am trying to keep my bias out of what I write on this site. But this actually introduces a problem I am still trying to solve. Some of the data refers to folic acid or methylfolate, and I do not agree with either, but there is more to this story that requires explaining. This is just one example. If you continue following my content you will likely hear me explain these various details along the way.

This is all about what you think, and I am attempting to provide you with better tools to figure out what to think.

I share a lot of short videos on my Facebook wall  https://www.facebook.com/micah.john.coffey and I often share the following videos which I think can help anyone increase their understanding of what we’re going for, even if they are still a little overwhelming.

I figured out how nutrients work and its kinda neat youtube.com/watch?v=0J8Qt6GC6FE

We’re doing it wrong  youtube.com/watch?v=qAxodqhpEkA

My old factory video from before I learned how to complicate this youtube.com/watch?v=0I3dWYbQpX4

If you are interested in iodine whyiodine.com

If you are trying to sort out the genetics situation methylate.me

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