Direct ConnectionsExtended NetworkFocus ViewNetwork ViewMethionine synthase reductase – regenerates MTR enzyme by reducing B12 cofactor. Key InformationFunctionKeeps MTR enzyme functionalCofactorsNADPH, FAD (B2)MutationsAssociated with neural tube defectsConnected PathwaysMTRMethylationMethionine synthase enzyme. Converts homocysteine to methionine using methylfolate and B12.Add to ViewB2B VitaminsRiboflavin. Critical cofactor for MTHFR and many other enzymes.Add to View