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Gene Patterns.

Genes don't act in isolation. They cluster into patterns. Understanding patterns is more useful than memorizing individual genes.

Why patterns matter.

Instead of asking "what does this gene do?"—ask "which pattern does this gene belong to?"

The old way

  • • "I have MTHFR C677T"
  • • "I have slow COMT"
  • • "I have APOE4"
  • • Each gene is a separate problem
  • • Supplement for each gene

The pattern approach

  • • "I have fragile methyl buffering"
  • • "I have slow clearance pattern"
  • • Multiple genes, same underlying issue
  • • Address the pattern, not each gene
  • • Fewer interventions, better outcomes

The patterns.

Things don't clear as fast

When detox pathways run slow, compounds linger. This affects how you handle caffeine, estrogen, histamines, and toxins.

Genes in this pattern

COMTGSTCYP1A2CYP2D6NAT2MAO

Common signs

  • Caffeine sensitivity
  • Histamine intolerance
  • Estrogen dominance
  • Chemical sensitivity
  • Poor drug metabolism

Methylation under pressure

When the methylation cycle struggles, you feel it in energy, mood, detox, and DNA repair. Not broken—just needs more support.

Genes in this pattern

MTHFRMTRMTRRBHMTMATAHCY

Common signs

  • Fatigue
  • Brain fog
  • Anxiety or depression
  • High homocysteine
  • Folate/B12 issues

Oxidative stress management

Antioxidant defenses are stretched thin. More vulnerable to inflammation, aging, and oxidative damage.

Genes in this pattern

SOD2CATGPX1GSTM1GSTP1NQO1

Common signs

  • Chronic inflammation
  • Premature aging signs
  • Poor exercise recovery
  • Environmental sensitivity
  • Low glutathione

Issues with fat-based nutrients

Trouble absorbing, transporting, or converting fat-soluble vitamins and fatty acids. Affects brain, skin, and hormones.

Genes in this pattern

APOEBCMO1FADS1FADS2MTTP

Common signs

  • Low vitamin A from plants
  • DHA deficiency signs
  • Dry skin or eyes
  • Cognitive concerns
  • Poor night vision

Sluggish bile and liver function

Bile is essential for fat digestion, toxin removal, and hormone clearance. When it's sluggish, everything backs up.

Genes in this pattern

UGT1A1ABCB4SLCO1B1CYP7A1

Common signs

  • Fat malabsorption
  • Nausea with fatty foods
  • Hormone imbalance
  • Gallbladder issues
  • Poor toxin clearance

Same genes, different outcomes.

Why do some people with "bad" gene variants thrive while others struggle? Because expression matters more than the gene itself.

What determines expression:

  • • Nutrient availability
  • • Sunlight and circadian rhythm
  • • Toxin and infection burden
  • • Stress and nervous system state
  • • Gut health and absorption
  • • Sleep quality and recovery

"The pattern reveals the pressure. Address the pressure, not the gene."

Explore individual genes.

Start with a specific gene, then follow the connections back to patterns.