HormoneAnabolic

Growth Hormone

The repair and regeneration hormone. Growth hormone (somatotropin) pulses from the pituitary gland during deep sleep and fasting. It promotes tissue repair, fat burning, muscle preservation, and bone density. Declines with age but can be naturally optimized through lifestyle.

Growth hormone release and effects
Pituitary
Source
Night
Peak Time
191 AA
Amino Acids
GHR
Receptor

What Growth Hormone Does

Fat Burning

Potent lipolytic hormone. Mobilizes fat stores for energy. Preserves muscle during fasting.

Muscle Building

Promotes protein synthesis via IGF-1. Increases lean body mass. Anti-catabolic.

Tissue Repair

Accelerates wound healing. Repairs damaged tissues. Regenerative effects throughout body.

Bone Density

Stimulates bone formation. Works with IGF-1 for skeletal health. Critical during development.

Immune Function

Supports immune cell function. GH decline may explain age-related immune weakness.

Organ Maintenance

Maintains organ size and function. Brain, heart, kidneys all have GH receptors.

GH Release Pattern

What Increases GH

  • Deep sleep: Largest pulses during first hours of sleep
  • Fasting: Dramatically rises during extended fasts
  • Intense exercise: HIIT, sprints, heavy lifting
  • Ghrelin: Hunger hormone stimulates GH
  • Low blood sugar: Hypoglycemia triggers GH

What Decreases GH

  • High insulin: Eating suppresses GH pulses
  • Poor sleep: Disrupted sleep = less GH
  • Obesity: Fat accumulation suppresses GH
  • High blood sugar: Glucose blunts GH response
  • Aging: GH declines 14% per decade after 30

Naturally Optimizing GH

Prioritize Deep Sleep

70-80% of daily GH released during sleep. Dark room, cool temp, consistent schedule.

Intermittent Fasting

Fasting boosts GH 5x. Don't eat 2-3 hours before bed. Consider time-restricted eating.

High Intensity Exercise

Sprints, heavy lifting, HIIT all boost GH. More intensity = more GH response.

Reduce Body Fat

Belly fat especially suppresses GH. Losing fat restores GH production.

Growth Hormone Discussion