p53
The guardian of the genome. p53 is the most important tumor suppressor protein in the body. When DNA is damaged, p53 halts cell division, activates repair, or triggers cell death if damage is beyond repair. Mutations in p53 are found in over 50% of human cancers. Supporting p53 function is central to cancer prevention.
p53 Functions
Cell Cycle Arrest
Stops division when DNA damaged. Gives time for repair. Prevents mutation propagation.
DNA Repair
Activates repair machinery. Fixes damaged DNA. Maintains genome integrity.
Apoptosis
Triggers cell death if damage unrepairable. Better dead than cancerous.
Senescence
Permanent growth arrest. Cells stop dividing forever. Alternative to apoptosis.
Metabolism Regulation
Regulates glucose, fat metabolism. Warburg effect connection.
Autophagy
Promotes cellular cleanup. Recycles damaged components.
What Activates p53
DNA Damage
Radiation, chemicals, oxidative stress. Primary activator.
Oncogene Activation
When cancer genes turn on, p53 responds. Failsafe mechanism.
Hypoxia
Low oxygen triggers p53. Tumors often hypoxic.
Nutrient Deprivation
Fasting activates p53. Cancer cells don't like fasting.
Supporting p53 Function
Fasting
Activates p53. Enhances DNA repair. Time-restricted eating helps.
Zinc
p53 is a zinc-finger protein. Needs zinc to function properly.
Sulforaphane
From broccoli. Supports p53 activity. Anticancer effects.
Curcumin
Reactivates mutant p53 in some studies. Anti-inflammatory.