GlandStress Response

Adrenal Health

Your stress command center. The adrenal glands sit atop your kidneys and orchestrate the stress response - producing cortisol, adrenaline, and other hormones. Chronic stress can dysregulate this system, leading to fatigue, anxiety, and metabolic dysfunction.

Adrenal glands and HPA axis
HPA
Axis Control
50+
Hormones Made
Vit C
Highest Here
Cortisol
Main Output

What the Adrenals Do

Cortisol Production

Primary stress hormone. Regulates blood sugar, metabolism, inflammation, and circadian rhythm.

Catecholamines

Adrenaline (epinephrine) and noradrenaline from the medulla. Fight-or-flight response.

DHEA

Precursor to sex hormones. Often called the "anti-aging" hormone. Opposes cortisol effects.

Aldosterone

Regulates sodium/potassium balance and blood pressure. Part of RAAS system.

Sex Hormone Precursors

Make androgens that convert to testosterone and estrogen. Important post-menopause.

HPA Axis Integration

Hypothalamus-Pituitary-Adrenal axis. Brain tells adrenals when to produce cortisol.

The Cortisol Rhythm

6-8 AM
Peak (CAR)

Cortisol awakening response. Wakes you up.

12 PM
Declining

Should be dropping through morning.

6 PM
Low

Should be much lower by evening.

12 AM
Lowest

Nadir at night for sleep.

Disrupted rhythm (flat, reversed, or erratic) indicates HPA axis dysfunction.

HPA Axis Dysregulation ("Adrenal Fatigue")

Chronic stress can dysregulate the HPA axis. Not technically "adrenal fatigue" but real dysfunction:

Early Stage (High Cortisol)

Wired but tired. Anxiety. Difficulty sleeping. Weight gain (especially belly). High blood sugar.

Later Stage (Low/Flat Cortisol)

Exhaustion. Can't wake up. Low blood pressure. Salt cravings. Poor stress tolerance. Frequent illness.

Reversed Pattern

Low morning cortisol, high evening cortisol. Can't wake up, can't fall asleep.

Associated Issues

Thyroid dysfunction, sex hormone imbalances, blood sugar issues, inflammation, immune suppression.

What Stresses the Adrenals

Psychological Stress

Work, relationships, finances, trauma. The brain can't distinguish mental from physical threat.

Blood Sugar Swings

Low blood sugar is a stress. Adrenals release cortisol to raise it. Roller coaster diet exhausts them.

Sleep Deprivation

Poor sleep raises cortisol. Elevated cortisol disrupts sleep. Vicious cycle.

Inflammation

Chronic infections, gut issues, autoimmunity all stimulate cortisol production.

Overtraining

Excessive exercise without recovery. Cortisol rises, DHEA drops, performance declines.

Stimulants

Caffeine, energy drinks force cortisol release. Masks fatigue while depleting reserves.

Supporting Adrenal Health

Reduce Stressors

Identify and address root causes. Boundaries, delegation, eliminating unnecessary stress.

Stabilize Blood Sugar

Protein with meals, avoid sugar spikes, don't skip meals when struggling.

Prioritize Sleep

7-9 hours. Consistent schedule. Dark, cool room. Avoid screens before bed.

Adaptogens

Ashwagandha, rhodiola, eleuthero, holy basil. Help modulate cortisol response.

Key Nutrients

Vitamin C (high concentration in adrenals), B5 (pantothenic acid), magnesium, zinc.

Gentle Movement

Walking, yoga, tai chi. Avoid intense exercise when depleted - it raises cortisol.

Adrenal Health Discussion