Biological ProcessMaster Clock

Circadian Rhythm

Your internal 24-hour clock. Nearly every cell in your body runs on a circadian rhythm, coordinating when to be active, when to rest, when to repair. Light is the master signal that keeps this orchestra in sync—and modern life constantly disrupts it.

Circadian rhythm and the 24-hour cycle
24.2h
Natural Cycle Length
SCN
Master Clock (Brain)
~40%
Genes Are Circadian
2017
Nobel Prize

What Follows Circadian Rhythm

Sleep-Wake Cycle

Melatonin rises at night, cortisol rises in morning. Body prepares for activity or rest.

Body Temperature

Drops at night for sleep onset. Rises before waking. Lowest around 4 AM.

Hormone Release

Growth hormone peaks during deep sleep. Testosterone highest in morning. Insulin sensitivity varies.

Metabolism

Blood sugar handling best in morning. Late eating = worse glucose response. Same food, different time.

Immune Function

Inflammatory markers peak at night. Immune surveillance varies throughout day.

Gene Expression

Clock genes (BMAL1, CLOCK, PER, CRY) control ~40% of all gene expression patterns.

Light: The Master Signal

Morning Light

  • Sunlight through eyes hits specialized ipRGCs
  • Signals SCN to stop melatonin production
  • Triggers cortisol awakening response
  • Sets the "start" of your circadian day
  • Earlier light = earlier sleep that night

Evening Light

  • Blue light after sunset suppresses melatonin
  • Shifts circadian clock later (phase delay)
  • Screens, LED lights are especially disruptive
  • Dim, warm light in evening is ideal
  • Darkness signal triggers sleep preparation

Consequences of Circadian Disruption

Shift work, jet lag, and screen use create chronic circadian misalignment with serious health consequences:

Metabolic Disease

Higher rates of obesity, diabetes, metabolic syndrome in shift workers and night owls.

Cardiovascular Risk

Heart attacks cluster in morning hours. Chronic disruption increases heart disease risk.

Mood & Mental Health

Depression, anxiety, bipolar disorder all linked to circadian disruption.

Cancer Risk

Night shift work classified as "probably carcinogenic" by WHO. Breast cancer risk elevated.

Cognitive Decline

Poor sleep and circadian disruption accelerate cognitive aging and dementia risk.

Immune Dysfunction

Vaccination response worse when sleep-deprived. Infection risk increases.

Optimizing Circadian Health

Morning Sunlight

Get bright light within 1-2 hours of waking. 10-30 min outside. Sets your clock.

Evening Light Control

Dim lights after sunset. Blue-blocking glasses. Night mode on devices. Red/amber lighting.

Consistent Schedule

Same wake time every day—even weekends. Consistency is more important than duration.

Meal Timing

Eat during daylight hours. Avoid eating close to bedtime. Time-restricted eating can help.

Temperature Cues

Cool bedroom for sleep. Morning warmth can help waking. Hot bath 1-2hr before bed.

Exercise Timing

Morning/afternoon exercise reinforces circadian rhythm. Late exercise can delay sleep.

Circadian Rhythm Discussion