HormoneFight or Flight

Epinephrine

The ultimate action hormone. Epinephrine (adrenaline) is released from adrenal glands in seconds during stress, priming your body for immediate action. Heart pounds, pupils dilate, airways open, blood rushes to muscles. Essential for survival, problematic when chronically elevated.

Epinephrine synthesis and effects
Seconds
Release Speed
2-3 min
Half-Life
Adrenals
Medulla
PNMT
Final Enzyme

What Epinephrine Does

Heart Rate

Increases heart rate and contraction force. More blood pumped per minute.

Blood Pressure

Constricts some vessels (skin, gut), dilates others (muscles). Redirects blood flow.

Airways

Dilates bronchioles. Improves airflow. Why EpiPen works for anaphylaxis.

Blood Sugar

Triggers glycogenolysis. Releases glucose from liver. Immediate fuel availability.

Pupils

Dilates pupils. Improves light intake. Better visual acuity for threats.

Fat Breakdown

Activates lipolysis. Releases fatty acids for energy. Mobilizes fuel stores.

Synthesis Pathway

Tyrosine
amino acid
L-DOPA
BH4 needed
Dopamine
B6 needed
Norepinephrine
vitamin C
Epinephrine
SAM-e (PNMT)

Problems with Chronic Elevation

Cardiovascular

High blood pressure, arrhythmias, increased heart disease risk from constant stimulation.

Anxiety

Racing heart, trembling, panic symptoms. Body stuck in fight-or-flight mode.

Burnout

Eventually adrenals fatigue. Can't mount appropriate stress response. Exhaustion.

Epinephrine Discussion