Hormone

Progesterone

The calming hormone. Progesterone balances estrogen, supports pregnancy, promotes sleep, and has natural anti-anxiety effects through its GABA-enhancing metabolite.

Progesterone synthesis and functions
Luteal
Peak Phase
10-25
Optimal ng/mL (Luteal)
P4
Medical Abbreviation
Corpus
Luteum Source

🌙 What Progesterone Does

Prepares Uterus

Builds uterine lining for implantation

Maintains Pregnancy

Essential until placenta takes over

Calms Nervous System

Metabolite enhances GABA

Promotes Sleep

Natural sedative effect

⚠️ The Pregnenolone Steal

Cholesterol → Pregnenolone is the first step in making all steroid hormones. Under stress, the body diverts pregnenolone toward cortisol production, "stealing" it from progesterone:

Normal State

Pregnenolone → Progesterone → downstream hormones (DHEA, testosterone, estrogen, cortisol balanced)

Chronic Stress

Pregnenolone → Cortisol (prioritized). Progesterone drops, causing estrogen dominance symptoms.

🔻 Signs of Low Progesterone

Menstrual

  • • Short luteal phase
  • • Irregular cycles
  • • Spotting before period

Mood

  • • Anxiety
  • • PMS mood swings
  • • Irritability

Sleep

  • • Insomnia
  • • Waking at night
  • • Night sweats

Fertility

  • • Difficulty conceiving
  • • Early miscarriage

Physical

  • • Bloating
  • • Breast tenderness
  • • Headaches

Other

  • • Brain fog
  • • Low libido

✅ Supporting Progesterone Production

Reduce Stress

Stop the pregnenolone steal

Vitamin B6

Supports corpus luteum function

Vitamin C

Increases progesterone levels

Zinc

Required for hormone production

Vitex (Chaste Tree)

May support luteal phase

Healthy Fats

Cholesterol is the precursor

Progesterone Discussion